4 ECTS credits
120 h study time
Offer 1 with catalog number 4023180ENR for all students in the 2nd semester at a (E) Master - advanced level.
Chapter 1: Introduction
Definitions, historical background, industrial and economic aspects, overview of the drug development process.
Chapter 2: Pharmacokinetics
Introduction, Absorption, Distribution, Metabolism, Excretion
Chapter 3: Pharmacodynamics
Introduction, Determination of drug-receptor interactions, binding forces, receptor types, radioligand competition binding, signal transduction mechanisms.
Chapter 4: Case studies
Examples include, but may vary:
bioisosterism
conformational constraints (e.g. cyclic peptides)
from serotonin to sumatryptan
development of Captopril
Chapter 5: Guest lectures by specialists from both industry and academia
Course material:
Recommended : Medicinal Chemistry, Principles and Practice, F.D. King, 2de, The Royal Society of Chemistry, 9780854046317, 2003
Recommended: An introduction to medicinal chemistry, G.L.Patrick, 6de, Oxford University Press, 9780198749691, 2017
Recommended : The practice of Medicinal Chemistry, C.G. Wermuth, 4de, Academic Press, 9780124172050, 2015
Compulsory : Handouts, including references and personal notes
The student understands:
the role of the organic chemist in the development of new drugs
pharmacokinetics: definition, principles and application thereof
pharmacodynamics: definition, principles and application thereof
drug design: basic principles and application thereof in the presented subjects/case studies
The final grade is composed based on the following categories:
Other Exam determines 100% of the final mark.
Within the Other Exam category, the following assignments need to be completed:
Written part (40% of final score) followed by an oral exam (40% of end score). Additionally, open book questions related to the guest lectures will account for 20% of the final score.
This combination permits to assess the students skills and insight into the subject matter.
This offer is part of the following study plans:
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Medical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Molecular Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Agrobiotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Food Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Chemical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Biochemical Biotechnology (only offered in Dutch)
Master of Chemistry: Default track (only offered in Dutch)
Master of Chemistry: Chemical Theory, (Bio)Molecular Design and Synthesis