4 ECTS credits
120 h study time

Offer 1 with catalog number 4023180ENR for all students in the 2nd semester at a (E) Master - advanced level.

Semester
2nd semester
Enrollment based on exam contract
Impossible
Grading method
Grading (scale from 0 to 20)
Can retake in second session
Yes
Enrollment Requirements
Students who want to enroll for this course, must have passed “Organische Chemie: Structuur" and "Organische Chemie: Reactiviteit"
Taught in
English
Faculty
Faculty of Sciences and Bioengineering Sciences
Department
Chemistry
Educational team
Steven Ballet (course titular)
Activities and contact hours
26 contact hours Lecture
13 contact hours Seminar, Exercises or Practicals
Course Content

Chapter 1:  Introduction 

Definitions, historical background, industrial and economic aspects, overview of the drug development process. 

 

Chapter 2: Pharmacokinetics 

Introduction, Absorption, Distribution, Metabolism, Excretion 

 

Chapter 3: Pharmacodynamics 

Introduction, Determination of drug-receptor interactions, binding forces, receptor types, radioligand competition binding, signal transduction mechanisms. 

 

Chapter 4: Case studies 
Examples include, but may vary: 

  • bioisosterism  

  • conformational constraints (e.g. cyclic peptides) 

  • from serotonin to sumatryptan 

  • development of Captopril 

 

Chapter 5: Guest lectures by specialists from both industry and academia 

Course material
Practical course material (Required) : Handouts, including references and personal notes
Handbook (Recommended) : Medicinal Chemistry, Principles and Practice, F.D. King, 2de, The Royal Society of Chemistry, 9780854046317, 2003
Handbook (Recommended) : An introduction to medicinal chemistry, G.L.Patrick, 6de, Oxford University Press, 9780198749691, 2017
Handbook (Recommended) : The practice of Medicinal Chemistry, C.G. Wermuth, 4de, Academic Press, 9780124172050, 2015
Additional info

Course material: 

Recommended : Medicinal Chemistry, Principles and Practice, F.D. King, 2de, The Royal Society of Chemistry, 9780854046317, 2003 

Recommended: An introduction to medicinal chemistry, G.L.Patrick, 6de, Oxford University Press, 9780198749691, 2017 

Recommended : The practice of Medicinal Chemistry, C.G. Wermuth, 4de, Academic Press, 9780124172050, 2015 
Compulsory : Handouts, including references and personal notes

Learning Outcomes

general competencies

The student understands: 

  • the role of the organic chemist in the development of new drugs 

  • pharmacokinetics: definition, principles and application thereof 

  • pharmacodynamics: definition, principles and application thereof 

  • drug design: basic principles and application thereof in the presented subjects/case studies 

Grading

The final grade is composed based on the following categories:
Other Exam determines 100% of the final mark.

Within the Other Exam category, the following assignments need to be completed:

  • written + oral + open book with a relative weight of 100 which comprises 100% of the final mark.

Additional info regarding evaluation

Written part (40% of final score) followed by an oral exam (40% of end score). Additionally, open book questions related to the guest lectures will account for 20% of the final score. 

This combination permits to assess the students skills and insight into the subject matter. 

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Medical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Molecular Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Agrobiotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Food Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Chemical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Biochemical Biotechnology (only offered in Dutch)
Master of Chemistry: Default track (only offered in Dutch)
Master of Chemistry: Chemical Theory, (Bio)Molecular Design and Synthesis