6 ECTS credits
158 h study time
Offer 1 with catalog number 4015831FNR for all students in the 2nd semester
at
a (F) Master - specialised level.
- Semester
- 2nd semester
- Enrollment based on exam contract
- Impossible
- Grading method
- Grading (scale from 0 to 20)
- Can retake in second session
- Yes
- Enrollment Requirements
- Registration for "Medicinal Chemistry" is allowed if one has successfully accomplished "Organic Chemistry".
- Taught in
- English
- Partnership Agreement
- Under interuniversity agreement for degree program
- Faculty
- Faculty of Science and Bio-engineering Sciences
- Department
- Chemistry
- Educational team
- Steven Ballet
(course titular)
- Activities and contact hours
-
26 contact hours Lecture
80 contact hours Seminar, Exercises or Practicals
- Course Content
Chapter 1: Introduction
Definitions, historical background, industrial and economic aspects, overview of the drug development process.
Chapter 2: Pharmacokinetics
Introduction, Absorption, Distribution, Metabolism, Excretion
Chapter 3: Pharmacodynamics
Introduction, Determination of drug-receptor interactions, binding forces, receptor types, radioligand competition binding, signal transduction mechanisms.
Chapter 4: Case studies
Examples include:
- bioisosterism cases
- conformational constraints (e.g. cyclic peptides)
- from serotonin to sumatryptan
- development of Captopril
Next to the lectures, a selected topic (from scientific publication or chapter of handbook on Medicinal Chemistry) is examined. All relevant background information is looked up.
This topic is presented in a 30 to 45 minute lasting oral presentation.
- Course material
- Handbook (Recommended) : Medicinal Chemistry, Principles and Practice, Principles and Practice, F.D. King, 2de, The Royal Society of Chemistry, 9780854046317, 2003
Handbook (Recommended) : An introduction to medicinal chemistry, G.L.Patrick, 5de, Oxford, 9780198749691, 2017
Course text (Required) : Medicinale chemie, Cursus en aantekeningen hoorcollege, Door de prof
Handbook (Recommended) : The practice of Medicinal Chemistry, C.G. Wermuth, 4de, Elsevier, 9780124172050, 2015
Digital course material (Required) : Powerpoint presentaties
- Additional info
NA
- Learning Outcomes
-
General Competencies
The student understands:
- the role of the organic chemist in the development of new drugs
- pharmacokinetics: definition, principles and application thereof
- pharmacodynamics: definition, principles and application thereof
- drug design: basic principles and application thereof in the presented subjects/case studies
- Grading
-
The final grade is composed based on the following categories:
Oral Exam determines 25% of the final mark.
Written Exam determines 50% of the final mark.
LEC Presentation determines 25% of the final mark.
Within the Oral Exam category, the following assignments need to be completed:
- Oral examination
with a relative weight of 1
which comprises 25% of the final mark.
Within the Written Exam category, the following assignments need to be completed:
- Written examination
with a relative weight of 1
which comprises 50% of the final mark.
Within the LEC Presentation category, the following assignments need to be completed:
- Presentation of an article
with a relative weight of 1
which comprises 25% of the final mark.
- Additional info regarding evaluation
Reading an article + presentation (maximum 45 min) is compulsory = 25% of final grade.
Oral and written exam = 75% of final grade.
- Allowed unsatisfactory mark
- The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.
Academic context
This offer is part of the following study plans:
Master of Molecular Biology: Standaard traject
Master of Teaching in Science and Technology: chemie (120 ECTS, Etterbeek) (only offered in Dutch)