3 ECTS credits
90 u studietijd

Aanbieding 1 met studiegidsnummer 1015659BNR voor alle studenten in het 2e semester met een verdiepend bachelor niveau.

Semester
2e semester
Inschrijving onder examencontract
Niet mogelijk
Beoordelingsvoet
Beoordeling (0 tot 20)
2e zittijd mogelijk
Ja
Inschrijvingsvereisten
Due to specific risks and security issues, students must have successfully passed ‘Organic Chemistry: Structural Aspects' and 'Organic Chemistry: Reactivity' before they can enroll for ‘Organic Chemistry: Methods of Synthesis’.
Onderwijstaal
Engels
Faculteit
Faculteit Wetenschappen en Bio-ingenieurswetensch.
Verantwoordelijke vakgroep
Chemie
Onderwijsteam
Steven Ballet (titularis)
Guido VERNIEST
Onderdelen en contacturen
26 contacturen Hoorcollege
26 contacturen Werkcolleges, practica en oefeningen
Inhoud

The next chapters are discussed during the lectures:

Retrosynthesis I: basic concepts
Retrosynthesis II; chemoselectivity and protecting groups
Retrosynthesis III: regioselectivity
Retrosynthesis VI: C-C disconnections
Aldol reactions - enols and enolates
Synthesis and reactions of beta-dicarbonyls
Enolates, enamines and aza-enolates

Practical exercises

The first laboratory exercises consist of the separation, purification and identification of two or three unknown compounds in a mixture or start with a Grignard reaction. The following synthesis subjects vary from year to year, depending on the supervisor. Examples are:  a malonate synthesis (beta-methylphenylalanine), a phase transfer-catalyzed alkylation of (diphenylmethylene)glycine ethyl ester, an oxidation reaction (indene to 2-indanone, followed by a Strecker-type synthesis (2-aminoindane-2-carboxylic acid).

Studiemateriaal
Handboek (Aanbevolen) : Organic Chemistry, Clayden, Greeves, Warren and Wothers, 2de, Oxford University Press, 9780199270293, 2012
Handboek (Aanbevolen) : Spectrometric identification of organic compounds, R.M. Silverstein and F.X. Webster, 8de, Wiley, 9780470616376, 2014
Handboek (Aanbevolen) : Reactions and syntheses in the organic chemistry laboratory, L.F. Tietze and Th. Eicher, 2de, Wiley, 9783527338146, 2015
Handboek (Aanbevolen) : Vogel's textbook of practical organic chemistry, Vogel, 3rd Ed, Longman, 9780582462366, 1996
Handboek (Aanbevolen) : Techniques and experiments for organic chemistry, Addison Ault, 3rd ed, Allyn and Bacon Inc, 9780935702767, 1998
Cursustekst (Vereist) : Organic chemistry: methods of synthesis, Powerpoint presentations, personal lecture notes and course (Dienst uitagven VUB), S. Ballet, VUB, 2220170007328, 2020
Bijkomende info

Laboratory exercises: In an introductory session the basic concepts of industrial toxicology and lab safety are taught. Additionally, some elemental techniques are shown (glassware, reflux setup, distillation, extraction, filtration, evaporation, crystallisation, cleaning)


Because this course is an English course in a Dutch curriculum, measures for language support (equivalent to 6 hours of lecture) are foreseen.

The laboratory exercises are compulsory. 

Leerresultaten

Algemene competenties

This course introduces the student to the methodology of designing organic synthesis pathways via retrosynthesis, and brings further knowledge of important synthetic reactions. 

This is situated within the bachelor target: to introduce the student in a main area in chemistry.

The laboratory exercises aims at the practical application of the theoretical part of the course. 

The learning targets are threefold:

  • learning the techniques of isolation (extraction) and purification (crystallization, distillation) and of the characterization of unknown compounds by spectroscopic techniques. 
  • to learn the techniques for performing typical organic reactions.
  • to learn and to implement safety aspects associated with experimental organic chemistry is a continuous concern in these sessions.

Beoordelingsinformatie

De beoordeling bestaat uit volgende opdrachtcategorieën:
Examen Mondeling bepaalt 80% van het eindcijfer

Examen Schriftelijk bepaalt 20% van het eindcijfer

Binnen de categorie Examen Mondeling dient men volgende opdrachten af te werken:

  • mondeling examen met een wegingsfactor 1 en aldus 80% van het totale eindcijfer.

Binnen de categorie Examen Schriftelijk dient men volgende opdrachten af te werken:

  • schriftelijk examen met een wegingsfactor 1 en aldus 20% van het totale eindcijfer.

Aanvullende info mbt evaluatie

Oral exam with written preparation on theoretical aspects

A retrosynthetic and additional exercise constitute the written exam.

The final score is composed as follows: Score Theory x4 + score Lab practical x1. 
 

For the evaluation of the practicals, the following categories and attitudes are quoted: reports, answer to questions during the exercises, preparation, performance in the laboratory, including correct experimental setup, cleanliness and organisation. Students who are illegitimately absent cannot retake the practical exercises and are quoted pro rata the amount of missed exercises. Students who were illegitimately absent on two practical sessions are excluded from the exam. There is no possibility to redo the practical exercises in the 2nd examination session (August/September). 

 
Toegestane onvoldoende
Kijk in het aanvullend OER van je faculteit na of een toegestane onvoldoende mogelijk is voor dit opleidingsonderdeel.

Academische context

Deze aanbieding maakt deel uit van de volgende studieplannen:
Bachelor in de chemie: Standaard traject