3 ECTS credits
78 h study time
Offer 1 with catalog number 1022152ANR for all students in the 2nd semester at a (A) Bachelor - preliminary level.
(based on ‘Janeway’s Immunobiology’)
Chapter 1: Basic concepts in immunology
Getting familiar with the most important components of the immune system as well as the basic principles of the innate and adaptive immune response
Chapter 2: Innate immunity
The first line of defense of our immune system, inflammation, complement system and the induced innate immune response, …
Chapter 3: Antigen recognition by B-cell and T-cell receptors
Structure of lymphocyte receptors, antibody-antigen interaction, antigen recognition by T cells
Chapter 4: The generation of lymphocyte antigen receptors
Generating diversity in immunoglobulins, T-cell receptor gene rearrangement, structural variation in immunoglobulin constant regions, …
Chapter 5: T cell-mediated immunity
Antigen presentation, priming of naïve T cells, different effector T cells, T cell-mediated cytotoxicity, …
Chapter 6: The humoral immune response
B-cell activation by T cells, distribution and function of different immunoglobulin classes, Fc receptors, …
Chapter 7: Adaptive immunity
The course of the adaptive immune response, immunological memory, …
Chapter 8: The mucosal immune system
The organization of the mucosal system, the mucosal response and regulation of mucosal immune responses
Chapter 9: Failure of the immune system
Pathogens that can evade the immune defenses, immune deficiency, AIDS, …
Chapter 10: Allergy and allergic diseases
Different types of hypersensitivity reactions (IgE/non-IgE-mediated reactions), …
Chapter 11: Autoimmunity and transplantation
Self-tolerance, discrimination self/non-self, examples of auto-immune diseases and underlying mechanisms, transplant rejection
Chapter 12: Manipulation of the immune system
Treatment of unwanted immune responses with emphasis on therapeutic targets/mechanisms, using the immune response to attack tumors, vaccination, … This chapter is a first introduction to therapeutic strategies that are based on manipulation of the immune system. The matter will be further covered in other subjects of the program (Clinical Pharmacology, 3rd Bach; Pharmaceutical Biotechnology, 3rd Bach; Cell, Gene and Tissue therapy, 1st Master)
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The student knows the basic principles of an immune response: what happens when a pathogenic agent enters the body and what are the different steps that will finally lead to pathogen elimination and possibly immunological memory. The student has insight in what can go wrong during an immune response, how this can lead to adverse effects and how this can be therapeutically targeted.
The final grade is composed based on the following categories:
Written Exam determines 100% of the final mark.
Within the Written Exam category, the following assignments need to be completed:
Written exam; open questions + multiple choice
This offer is part of the following study plans:
Bachelor of Pharmaceutical Sciences: default (only offered in Dutch)
Bachelor of Pharmaceutical Sciences: Verkort traject (only offered in Dutch)