3 ECTS credits
78 h study time
Offer 1 with catalog number 4015920FNR for all students in the 1st semester
at
a (F) Master - specialised level.
- Semester
- 1st semester
- Enrollment based on exam contract
- Impossible
- Grading method
- Grading (scale from 0 to 20)
- Can retake in second session
- Yes
- Enrollment Requirements
- Registration for “Synthesis and Structure of Peptides” is allowed if one has succesfully accomplished “Organic chemistry: structure” and “Organisc chemistry: reactivity”.
- Taught in
- English
- Partnership Agreement
- Under interuniversity agreement for degree program
- Faculty
- Faculty of Science and Bio-engineering Sciences
- Department
- Chemistry
- Educational team
- Dirk Tourwe
Steven Ballet
(course titular)
- Activities and contact hours
-
13 contact hours Lecture
13 contact hours Seminar, Exercises or Practicals
13 contact hours Independent or External Form of Study
- Course Content
1.Introduction:
- What are peptides?
- Why study peptides?
2. Peptide synthesis:
- Protection schemes
- Coupling procedures
- Strategy - Solution synthesis
- Solid phase synthesis
3. Peptide conformations:
- General aspects : flexibility
- Secondary structure elements
- Conformational analysis by NMR
-An example
-Conformation and biological activity - Pseudopeptides and mimetics (an introduction)
4. Limitations of natural peptides:
- Conformational constraints
- Replacements of the peptide bond
- Metabolic stabilization
- Enzyme inhibitors
- Synthetic methods
- Course material
- Course text (Required) : Course text and lecture notes, Door de prof
Handbook (Recommended) : The chemical synthesis of peptides, J. Jones, 2de, Clarendon Press, 9781574444544, 2005
Handbook (Recommended) : Amino acid and peptide synthesis, A Practical Approach, John Jones, 2de, Oxford chemistry primers, 9780199637249, 1999
Handbook (Recommended) : Chemical Approaches to the Synthesis of Peptides and Proteins, Paul Lloyd-Williams - Fernando Albericio - Ernest Giralt, CRC Press, 9780849391422, 1997
- Additional info
A visit to a company, specialized in the industrial synthesis of peptides, is scheduled.
Complementary study material:
Chemistry of Peptide Synthesis, N. Leo Benoiton. Taylor & Francis, Boca Raton, FL. 2006.
Synthesis of Peptides and Peptidomimetics, Ed. M. Goodman, Houben-Weyl Methods of Organic Synthesis, vol E 22, Thieme, Stuttgart 2002
Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series), Ed. W. C. Chan, Peter D. White, Oxford Univesity Press, 2000.
Chemical Approaches to the Synthesis of Peptides and Proteins (New Directions in Organic & Biological Chemistry), Paul Lloyd-Williams, Fernando Albericio, Ernest Giralt, CRC Press 1997.
- Learning Outcomes
-
General Competences
The student
- knows how to design and synthesize a peptide
- possesses insights on the conformation adopted by small peptides
- possesses knowledge of recent research and industrial developments in the peptide field
- Grading
-
The final grade is composed based on the following categories:
Oral Exam determines 100% of the final mark.
Within the Oral Exam category, the following assignments need to be completed:
- Examen theorie/artikel
with a relative weight of 1
which comprises 100% of the final mark.
- Additional info regarding evaluation
During the exam the student will be asked to:
Present a scientific publication (prepared in advance) on peptide synthesis
Propose a strategy for a virtual peptide synthesis and discuss all used methods
Discuss a specific conformational problem
- Allowed unsatisfactory mark
- The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.
Academic context
This offer is part of the following study plans:
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Medical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Molecular Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Agrobiotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Food Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Chemical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Biochemical Biotechnology (only offered in Dutch)