3 ECTS credits
90 u studietijd
Aanbieding 1 met studiegidsnummer 1015659BNR voor alle studenten in het 2e semester met een verdiepend bachelor niveau.
The next chapters are discussed during the lectures:
Retrosynthesis I: basic concepts
Retrosynthesis II; chemoselectivity and protecting groups
Retrosynthesis III: regioselectivity
Retrosynthesis VI: C-C disconnections
Aldol reactions - enols and enolates
Synthesis and reactions of beta-dicarbonyls
Enolates, enamines and aza-enolates
Practical exercises
The first laboratory exercises consist of the separation, purification and identification of two or three unknown compounds in a mixture or start with a Grignard reaction. The following synthesis subjects vary from year to year, depending on the supervisor. Examples are: a malonate synthesis (beta-methylphenylalanine), a phase transfer-catalyzed alkylation of (diphenylmethylene)glycine ethyl ester, an oxidation reaction (indene to 2-indanone, followed by a Strecker-type synthesis (2-aminoindane-2-carboxylic acid).
Laboratory exercises: In an introductory session the basic concepts of industrial toxicology and lab safety are taught. Additionally, some elemental techniques are shown (glassware, reflux setup, distillation, extraction, filtration, evaporation, crystallisation, cleaning)
Because this course is an English course in a Dutch curriculum, measures for language support (equivalent to 6 hours of lecture) are foreseen.
The laboratory exercises are compulsory.
This course introduces the student to the methodology of designing organic synthesis pathways via retrosynthesis, and brings further knowledge of important synthetic reactions.
This is situated within the bachelor target: to introduce the student in a main area in chemistry.
The laboratory exercises aims at the practical application of the theoretical part of the course.
The learning targets are threefold:
De beoordeling bestaat uit volgende opdrachtcategorieën:
Examen Mondeling bepaalt 80% van het eindcijfer
Examen Schriftelijk bepaalt 20% van het eindcijfer
Binnen de categorie Examen Mondeling dient men volgende opdrachten af te werken:
Binnen de categorie Examen Schriftelijk dient men volgende opdrachten af te werken:
Oral exam with written preparation on theoretical aspects
A retrosynthetic and additional exercise constitute the written exam.
The final score is composed as follows: Score Theory x4 + score Lab practical x1.
For the evaluation of the practicals, the following categories and attitudes are quoted: reports, answer to questions during the exercises, preparation, performance in the laboratory, including correct experimental setup, cleanliness and organisation. Students who are illegitimately absent cannot retake the practical exercises and are quoted pro rata the amount of missed exercises. Students who were illegitimately absent on two practical sessions are excluded from the exam. There is no possibility to redo the practical exercises in the 2nd examination session (August/September).
Deze aanbieding maakt deel uit van de volgende studieplannen:
Bachelor in de chemie: Standaard traject