3 ECTS credits
90 h study time
Offer 1 with catalog number 1015659BNR for all students in the 2nd semester at a (B) Bachelor - advanced level.
The next chapters are discussed during the lectures:
Retrosynthesis I: basic concepts
Retrosynthesis II; chemoselectivity and protecting groups
Retrosynthesis III: regioselectivity
Retrosynthesis VI: C-C disconnections
Aldol reactions - enols and enolates
Synthesis and reactions of beta-dicarbonyls
Enolates, enamines and aza-enolates
Practical exercises
The first laboratory exercises consist of the separation, purification and identification of two or three unknown compounds in a mixture or start with a Grignard reaction. The following synthesis subjects vary from year to year, depending on the supervisor. Examples are: a malonate synthesis (beta-methylphenylalanine), a phase transfer-catalyzed alkylation of (diphenylmethylene)glycine ethyl ester, an oxidation reaction (indene to 2-indanone, followed by a Strecker-type synthesis (2-aminoindane-2-carboxylic acid).
Laboratory exercises: In an introductory session the basic concepts of industrial toxicology and lab safety are taught. Additionally, some elemental techniques are shown (glassware, reflux setup, distillation, extraction, filtration, evaporation, crystallisation, cleaning)
Because this course is an English course in a Dutch curriculum, measures for language support (equivalent to 6 hours of lecture) are foreseen.
The laboratory exercises are compulsory.
This course introduces the student to the methodology of designing organic synthesis pathways via retrosynthesis, and brings further knowledge of important synthetic reactions.
This is situated within the bachelor target: to introduce the student in a main area in chemistry.
The laboratory exercises aims at the practical application of the theoretical part of the course.
The learning targets are threefold:
The final grade is composed based on the following categories:
Oral Exam determines 80% of the final mark.
Written Exam determines 20% of the final mark.
Within the Oral Exam category, the following assignments need to be completed:
Within the Written Exam category, the following assignments need to be completed:
Oral exam with written preparation on theoretical aspects
A retrosynthetic and additional exercise constitute the written exam.
The final score is composed as follows: Score Theory x4 + score Lab practical x1.
For the evaluation of the practicals, the following categories and attitudes are quoted: reports, answer to questions during the exercises, preparation, performance in the laboratory, including correct experimental setup, cleanliness and organisation. Students who are illegitimately absent cannot retake the practical exercises and are quoted pro rata the amount of missed exercises. Students who were illegitimately absent on two practical sessions are excluded from the exam. There is no possibility to redo the practical exercises in the 2nd examination session (August/September).
This offer is part of the following study plans:
Bachelor of Chemistry: Default track (only offered in Dutch)